Vitamin E TPGS, a water soluble derivative of natural Vitamin E, is a multirole excipient for pharmaceutical drug delivery innovation. Vitamin E TPGS is a non-ionic surfactant used as:
- solubilizer of poorly soluble drugs
- absorption enhancer
- vehicle for lipid-based drug formulation
Vitamin E TPGS is also used as an efficient source of natural Vitamin E both for therapeutic and nutrition purposes.
Vitamin E TPGS in drug formulation
Vitamin E TPGS has been used mainly in oral dosage forms for years but new delivery applications are being investigated in parenteral, nasal, ophthalmic, dermal deliveries
- Enhancement of Bioavailability by increasing solubility of poorly water-soluble APIs and by formulation of Self Emulsifying Drug Delivery System (SEEDS)
- Thermal stability for hot melt extrusion as a versatile plasticizer with solubilizer properties and as Antioxidant for sensitive excipients
Formulation using TPGS has been developed for commercial drugs :
Two anti HIV drugs, AGENERASE® (Amprenavir) soft gel capsules and oral solution and APTIVUS® (Tripanavir) oral solution
One anti HCV drug, VIEKERA Pack™ (combination of 3 APIs) tablets
ISOCHEM offers large production capacity for both NF grade according to USP/NF monography and API grade according to US Type II drug master file (DMF number : 23823). Large quantities are supplied upon order and samples for development and qualification are available upon request.
ISOCHEM offers TPGS analogues with Polyethylene glycol chain molecular weight of 400, 1500 and 2000g/mol. Standard TPGS has a Polyethylene glycol molecular weight of 1000g/mol.
Technical and Quality support
ISOCHEM offers to its clients :
technical support for storage and handling
information for quality and pharmaceutical regulatory