NCA - UNCA

ISOCHEM produces at scales from gram to ton quantities of α-aminoacid N-CarboxyAnhydrides (NCAs) and  Urethane N-Carboxyanhydride (UNCAs). ​

NCAs and UNCAs have proven a great interest in two main areas:
          •  monomers for Ring Opening Polymerization (ROP) for NCAs
          •  powerful building blocks for smooth and eco-friendly coupling reaction with various nucleophiles for NCAs and UNCAs​​

ISOCHEM offers about 60 NCAs and the synthesis on demand of new NCAs or UNCAs including derivatives of non natural α-aminoacids.​

Search for NCA-UNCA Products

 

Applications​

Peptide based therapeutic polymers: NCAs are strategic building blocks for the preparation of polyaminoacid architectures for polymer drugs or polypeptide carriers in drug delivery and targeting technologies. Expanding the range of available NCA monomers including side chain functionalized α-aminoacids, offers post-polymerization modifications which broaden the perspectives of α-aminoacid based polymer therapeutics. ​​​

α-aminoacids coupling in APIs synthesis: UNCAs are now an established and attractive alternative to traditional α-aminoacid activation strategies for coupling reactions. ​The strength of this technology for industrial processes is demonstrated by its lower environmental and safety impact when compared to other coupling agent strategies.​ It also offers product purity profile advantage due to the reaction selectivity and the absence of any coupling reagent.​
 

 

Logistic solution and support ​​

 

  • Packaging: moisture proof double sealed bag. ​​

     

  • Transportation: frigipack for small quantities, insulated box with dry 
    ice, reefer container for large quantities with temperature monitoring set​​.

     

  • Stability and storage: storage under nitrogen, at temperatures of
    - 20°C +/- 5°C or 0°+/- 5°C depending on the stability of the NCA.
     

  • Handling: allow the package to warm up to room temperature before 
    opening and handle under dry and inert atmosphere.​​

 

 

 

 

For more detailed technical support, please contact us

Download NCA’s brochure

Reference : Yves Robin, Chemistry Today, 33(4) July-August 2015

 

Displaying 21 - 40 of 61

D-Glu(OBzl)-NCA

CAS Number: 
13822-45-2
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Phosgenated amino-acid, N-carboxyanhydride derivative

D-Orn(Boc)-NCA

CAS Number: 
1377983-29-3
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Phosgenated amino-acid, N-carboxyanhydride derivative

EPAL-NCA

CAS Number: 
84793-24-8
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Phosgenated amino-acid, N-carboxyanhydride derivative

Fmoc-Ile-NCA

CAS Number: 
129288-41-1
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Phosgenated amino-acid, N-carboxyanhydride derivative

Fmoc-Leu-NCA

CAS Number: 
125814-21-3
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Phosgenated amino-acid, N-carboxyanhydride derivative

Fmoc-Val-NCA

CAS Number: 
129288-47-7
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Phosgenated amino-acid, N-carboxyanhydride derivative

Glu(OBzl)-NCA

CAS Number: 
3190-71-4
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Phosgenated amino-acid, N-carboxyanhydride derivative

Glu(OMe)-NCA

CAS Number: 
1663-47-4
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Phosgenated amino-acid, N-carboxyanhydride derivative

Glu(OtBu)-NCA

CAS Number: 
86409-29-2
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Phosgenated amino-acid, N-carboxyanhydride derivative

Gly-NCA

CAS Number: 
2185-00-4
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Phosgenated amino-acid, N-carboxyanhydride derivative

Ile-NCA

CAS Number: 
45895-90-7
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Phosgenated amino-acid, N-carboxyanhydride derivative

Leu-NCA

CAS Number: 
3190-70-3
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Phosgenated amino-acid, N-carboxyanhydride derivative

Lys(Boc)-NCA

CAS Number: 
33043-60-6
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Phosgenated amino-acid, N-carboxyanhydride derivative

Lys(TFA)-NCA

CAS Number: 
42267-27-6
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Phosgenated amino-acid, N-carboxyanhydride derivative

Lys(Z)-NCA

CAS Number: 
1676-86-4
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Phosgenated amino-acid, N-carboxyanhydride derivative

Met-NCA

CAS Number: 
15776-11-1
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Phosgenated amino-acid, N-carboxyanhydride derivative

Moc-Ile-NCA

CAS Number: 
1428447-99-7
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Phosgenated amino-acid, N-carboxyanhydride derivative

Moc-Leu-NCA

CAS Number: 
NA
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Phosgenated amino-acid, N-carboxyanhydride derivative