25th anniversary of Union des Industries Chimiques
ISOCHEM participating in the celebration of the 25th anniversary of Union des Industries Chimiques (UIC) Responsible Care® membership.
ISOCHEM participating in the celebration of the 25th anniversary of Union des Industries Chimiques (UIC) Responsible Care® membership.
Yves Robin, Chemistry Today, 33(4) July-August 2015
http://www.teknoscienze.com/articles/chimica-oggi-chemistry-today--alph…
An overview of NCA innovations are shown below in three main points:
Yves Robin, Chemistry Today , 33(4) July-August 2015 - Yves Robin
http://www.teknoscienze.com/articles/chimica-oggi-chemistry-today--alph…
An overview of NCA innovations are shown below in three main points:
Keywords
α-amino acid N-Carboxy Anhydrides, NCA, Urethane α-Amino acid N-Carboxy Anhydrides, UNCA, Ring Opening Polymerization, ROP, Peptide, Polypeptide, Polyamino acid, Amino acid coupling, Drug delivery, Active pharmaceutical ingredient.
Abstract
α-Amino acid α-Carboxy Anhydrides (NCA) have been discovered over a century ago (1). The first significant development and use of NCAs in the pharmaceutical industry started during the second half of the 20th century while the interest of chemists revealed three major areas for innovation: 1) their preparation 2) their use in ring opening polymerization and copolymerization (ROP) reactions for polyamino acid synthesis and 3) their use in coupling reactions for α-amino acid derivatives or peptide fragment synthesis.
A natural Vitamin E derivative is an innovative excipient - Yves Robin, Pharmaceutical Technology - January 2015
https://www.pixelmags.com/awrv1/#magazines/1367/issues/110846/pages/51
Abstract
Tocophersolan or d-α-tocopheryl polyethylene glycol succinate (TPGS) was developed 60 years ago as a water-soluble form of vitamin E. Its surfactant properties triggered the interest of drug formulation developers before it steadily moved into the toolbox of pharmaceutical drug-delivery innovators. The author gives an overview of TPGS, including its interesting properties, examples found in the literature, and a brief summary of the regulatory status and marketed formulations.
One-Pot Synthesis of Dipeptides and Unsymmetrical Peptidyl Ureas from Unprotected NCA, Synthesis of Dipeptides and Unsymmetrical Peptidyl Ureas
Julia Mateos-Caro, Yves Robin, Vincent Levacher,* Francis Marsais , Synlett 2009 pp 279-283
Keywords
N-protected carboxyanhydrides (NCA) - peptidyl ureas - dipeptides
Abstract
We report herein new labile protecting groups of N-carboxyanhydrides (NCA) useful to prevent polymerization during coupling reactions with nitrogen nucleophiles. Thus, N-sulfinyl-NCA 1 and N-silyl-NCA 2 were prepared in situ and involved, without being isolated, in coupling reactions with various α-amino esters to furnish dipeptides 3 and unsymmetrical peptidyl ureas 4, respectively, in good yields.
V. Dureisseix, M.Sanselme, J.Y. Robin, G.Coquerel
Crystal Growth and Design; 2009 Vol 9, Issue 8, pp 3438–3443
Chimica oggi / Chemistry Today Vol 29 N°4 July/August 2011; Mikaël Paugam.
Chimica oggi / ChemistryToday Vol 27 N°5 September-October 2009; Yves Robin.
Specialty Chemical Magazine June 2009; Yves Robin.